PUBLICATIONS

Bacteria-derived anti-cancer agents

Choi JK#, Naffouje SA#, Goto M, Wang J, Christov K, Rademacher DJ, Green A, Stecenko AA, Chakrabarty AM, Das Gupta TK, Yamada T. (2023). Cross-talk between cancer and Pseudomonas aeruginosa mediates tumor suppression. Commun Biol. 6;6(1):16.

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Signorelli, S., Santini, S., Yamada, T., Bizzarri, A. R., Beattie, C. W. & Cannistraro, S. (2017). Binding of Amphipathic Cell Penetrating Peptide p28 to Wild Type and Mutated p53 as studied by Raman, Atomic Force and Surface Plasmon Resonance spectroscopies. Biochim Biophys Acta Gen Subj 1861(4), 910–921.

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Yamada, T., Gupta, T. K. D. & Beattie, C. W. (2016). p28-Mediated Activation of p53 in G2–M Phase of the Cell Cycle Enhances the Efficacy of DNA Damaging and Antimitotic Chemotherapy. Cancer Res, 76(8), 2354–2365. 

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Yamada, T., Signorelli, S., Cannistraro, S., Beattie, C. W. & Bizzarri, A. R. (2015). Chirality switching within an anionic cell-penetrating peptide inhibits translocation without affecting preferential entry. Mol Pharm, 12, 140–149.

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Coppari, E., Yamada, T., Bizzarri, A. R., Beattie, C. W. & Cannistraro, S. (2014). A nanotechnological, molecular-modeling, and immunological approach to study the interaction of the anti-tumorigenic peptide p28 with the p53 family of proteins. Int J Nanomedicine, 9, 1799–1813. 

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Santini, S., Bizzarri, A. R., Yamada, T., Beattie, C. W. & Cannistraro, S. (2014). Binding of azurin to cytochrome c 551 as investigated by surface plasmon resonance and fluorescence. J Mol Recognit, 27(3), 124–130.

Shilkaitis, A., Bratescu, L., Green, A., Yamada, T. & Christov, K. (2013). Bexarotene Induces Cellular Senescence in MMTV-Neu Mouse Model of Mammary Carcinogenesis. Cancer Prev Res (Phila), 6, 299–308.  

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Yamada, T., Gupta, T. K. D. & Beattie, C. W. (2013). p28, an Anionic Cell-Penetrating Peptide, Increases the Activity of Wild Type and Mutated p53 without Altering Its Conformation. Mol Pharm, 10(9), 3375–3383.

Yamada, T., Christov, K., Shilkaitis, A., Bratescu, L., Green, A., Santini, S., Bizzarri, A. R., Cannistraro, S., Gupta, T. K. & Beattie, C. W. (2013). p28, a first in class peptide inhibitor of cop1 binding to p53. Br J Cancer, 108, 2495–2504.

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Bizzarri, A. R., Santini, S., Coppari, E., Bucciantini, M., Agostino, S. D., Yamada, T., Beattie, C. W. & Cannistraro, S. (2011). Interaction of an anticancer peptide fragment of azurin with p53 and its isolated domains studied by atomic force spectroscopy. Int J Nanomedicine, 6, 3011–3019. 

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Mehta, R. R., Yamada, T., Taylor, B. N., Christov, K., King, M. L., Majumdar, D., Lekmine, F., Tiruppathi, C., Shilkaitis, A., Bratescu, L., Green, A., Beattie, C. W. & Gupta, T. K. D. (2011). A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 14:355–69. 

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Yamada, T., Mehta, R. R., Lekmine, F., Christov, K., King, M. L., Majumdar, D., Shilkaitis, A., Green, A., Bratescu, L., Beattie, C. W. & Gupta, T. K. D. (2009). A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol Cancer Ther. 8:2947–58.

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Taylor, B. N., Mehta, R. R., Yamada, T., Lekmine, F., Christov, K., Chakrabarty, A. M., Green, A., Bratescu, L., Shilkaitis, A., Beattie, C. W. & Gupta, T. K. D. (2009). Noncationic peptides obtained from azurin preferentially enter cancer cells. Cancer Res. 69:537–46.

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Chaudhari, A., Mahfouz, M., Fialho, A. M., Yamada, T., Granja, A. T., Zhu, Y., Hashimoto, W., Schlarb-Ridley, B., Cho, W., Gupta, T. K. D. & Chakrabarty, A. M. (2007). Cupredoxin-cancer interrelationship: azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth. Biochemistry. 46:1799–810. 

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Hong, C. S., Yamada, T., Hashimoto, W., Fialho, A. M., Gupta, T. K. D. & Chakrabarty, A. M. (2006). Disrupting the entry barrier and attacking brain tumors: the role of the Neisseria H.8 epitope and the Laz protein. Cell Cycle. 5:1633–41.

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Chaudhari, A., Fialho, A. M., Ratner, D., Gupta, P., Hong, C. S., Kahali, S., Yamada, T., Haldar, K., Murphy, S., Cho, W., Chauhan, V. S., Gupta, T. K. D. & Chakrabarty, A. M. (2006). Azurin, Plasmodium falciparum Malaria and HIV/AIDS: Inhibition of Parasitic and Viral Growth by Azurin. Cell Cycle, 5(15), 1642–1648. 

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Hiraoka, Y., Granja, A. T., Fialho, A. M., Schlarb-Ridley, B. G., Gupta, T. K. D., Chakrabarty, A. M. & Yamada, T. (2005). Human cytochrome c enters murine J774 cells and causes G1 and G2/M cell cycle arrest and induction of apoptosis. Biochem Biophys Res Commun 338(2), 1284–1290. 

Yamada, T., Fialho, A. M., Punj, V., Bratescu, L., Gupta, T. K. D. & Chakrabarty, A. M. (2005).  Internalization of bacterial redox protein azurin in mammalian cells: entry domain and specificity. Cell Microbiol. 7:1418–31. 

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Yamada, T., Hiraoka, Y., Ikehata, M., Kimbara, K., Avner, B. S., Gupta, T. K. D. & Chakrabarty, A. M. (2004). Apoptosis or growth arrest: Modulation of tumor suppressor p53’s specificity by bacterial redox protein azurin. Proc Natl Acad Sci USA. 101:4770–5.

Hiraoka, Y., Yamada, T., Goto, M., Gupta, T. K. D. & Chakrabarty, A. M. (2004). Modulation of mammalian cell growth and death by prokaryotic and eukaryotic cytochrome c.Proc Natl Acad Sci USA., 101(17), 6427–6432. 

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Punj, V., Bhattacharyya, S., Saint-Dic, D., Vasu, C., Cunningham, E. A., Graves, J., Yamada, T., Constantinou, A. I., Christov, K., White, B., Li, G., Majumdar, D., Chakrabarty, A. M. & Gupta, T. K. D. (2004).  Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer. Oncogene. 23:2367–2378.

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Yamada, T., Hiraoka, Y., Gupta, T. K. D. & Chakrabarty, A. M. (2004). Rusticyanin, a bacterial electron transfer protein, causes G1 arrest in J774 and apoptosis in human cancer cells. Cell Cycle (Georgetown, Tex.), 3(9), 1182–1187

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Yamada, T., Hiraoka, Y., Gupta, T. K. D. & Chakrabarty, A. M. (2004). Regulation of mammalian cell growth and death by bacterial redox proteins: relevance to ecology and cancer therapy. Cell Cycle (Georgetown, Tex.), 3(6), 752–755.

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Goto, M., Yamada, T., Kimbara, K., Horner, J., Newcomb, M., Gupta, T. K. D. & Chakrabarty, A. M. (2003).  Induction of apoptosis in macrophages by Pseudomonas aeruginosa azurin: tumour-suppressor protein p53 and reactive oxygen species, but not redox activity, as critical elements in cytotoxicity. Mol Microbiol. 47:549–59. 

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Yamada, T., Goto, M., Punj, V., Zaborina, O., Chen, M. L., Kimbara, K., Majumdar, D., Cunningham, E., Gupta, T. K. D. & Chakrabarty, A. M. (2002). Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer. Proc Natl Acad Sci USA 99:14098–103. 

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Yamada, T., Goto, M., Punj, V., Zaborina, O., Kimbara, K., Gupta, T. K. D. & Chakrabarty, A. M. (2002). The bacterial redox protein azurin induces apoptosis in J774 macrophages through complex formation and stabilization of the tumor suppressor protein p53. Infect Immun, 70, 7054–7062.